This month’s key articles were selected by Ryan Chadha, Dhupal Patel, Alexandra Shingina, David Nasralla, Eleonora DeMartin, and Sadhana Shankar.

HEPATOLOGY

Transplantation
Nodular Regenerative Hyperplasia Is Not a Rare Condition After Liver Transplantation: Incidence, Predictive Factors, and Impact on Survival
The objectives of this study were to evaluate incidence and to identify the risk factors of occurrence and the predictive factors of symptomatic forms of nodular regenerative hyperplasia (NRH) after liver transplantation (LT). More

Pharmacotherapy
Consensus recommendations for use of maintenance immunosuppression in solid organ transplantation: Endorsed by the American College of Clinical Pharmacy, American Society of Transplantation, and International Society for Heart and Lung Transplantation: An executive summary
Advances in maintenance immunosuppression over the past three decades have improved solid organ transplantation outcomes dramatically. Uninterrupted access to immunosuppression is paramount to minimize rejection and maintain allograft and patient survival. Agents used vary based on transplanted organ, center-specific protocol, provider expertise, insurance formularies, ability to cover co-pays, recipient characteristics and tolerability. More

Clinical Transplantation
Predictors of renal recovery in recipients of liver transplant alone who met 2017 simultaneous liver-kidney transplant criteria
Severe renal dysfunction is common among liver transplant (LT) candidates and often prompts simultaneous liver-kidney transplantation (SLKT) consideration. In view of 2017 United Network of Organ Sharing (UNOS) criteria for SLKT, we investigated the likelihood and predictors of renal recovery among patients who met the aforementioned criteria yet received liver transplant alone (LTA). More

SURGERY

Annals of Surgery
Transplantation for Nonresectable Colorectal Liver Metastases – Long Term follow- up of the First Prospective Pilot Study
Objective: To determine whether liver transplantation (LT) can provide long-term overall survival (OS) in selected patients with nonresectable liver-only colorectal liver metastases (nrCRLM). More

American Journal of Transplantation
Long-term outcomes of resection versus transplantation for neuroendocrine liver metastases meeting the Milan criteria
Liver resection (LR) is considered the treatment of choice for resectable neuroendocrine liver metastases (NELM), while liver transplantation (LT) is currently reserved for highly selected unresectable patients. We retrospectively analyzed data from consecutive patients undergoing either curative resection or transplantation for liver-only NELM meeting Milan criteria at a single center between 1984 and 2019. More

Transplantation
Impact of Older Donor Age on Recipient and Graft Survival After LDLT: The US Experience
Background: The impact of selecting older donors for living donor liver transplantation (LDLT) in the United States is incompletely studied, particularly in light of the recent expansion of LDLT nationally. More

ANESTHESIOLOGY AND CRITICAL CARE

Transplantation
Urgent Liver Transplantation for Acute Liver Failure in Pregnant Women: The Optimum Timing for Delivery
Background: The occurrence of acute liver failure (ALF) in pregnant women due to an etiology unrelated to pregnancy (pregALF) that leads to liver transplantation (LT) has rarely been reported. The objective was to report the outcome of pregnant women and fetus and propose a strategy for the timing of delivery and of LT in these patients. More

Respiratory Medicine
Pulmonary vascular disease and exercise hemodynamics in chronic liver disease
Background & aims: Portopulmonary hypertension (POPH) and hepatopulmonary syndrome (HPS) are severe pulmonary vascular complications of chronic liver disease and strongly associated with morbidity and mortality. The prevalence of these complications is relatively high in patients evaluated for liver transplantation, however it is virtually unknown in patients with stable chronic liver disease. More

Intensive Care Medicine
Artificial liver support in patients with liver failure: a modified DELPHI consensus of international experts
The present narrative review on albumin dialysis provides evidence-based and expert opinion guidelines for clinicians caring for adult patients with different types of liver failure. The review was prepared by an expert panel of 13 members with liver and intensive care expertise in extracorporeal liver support therapies for the management of patients with liver failure. More